"10/10! Brain fog has disappeared! My mood is stabilized. I feel clear headed and sharp - which makes a huge difference in my career."
"Been taking this for a long time - I can remember the feeling after 1-2 months when it felt like something clicked in my mind and my memory. Planning on taking this as long as I can!"
"I love this product. I look forward to taking it every morning for the calming effect and for helping to clear my busy mind. I strongly recommend Lucidum Brain and Nerves Formula."
Lion's mane is well known for memory and cognitive support, and multiple clinical trials demonstrate lion's mane’s ability to significantly improve memory and cognition in adults. Animal trials suggest that lion's mane also speeds recovery time after damage to peripheral nerves, and additional research shows improvements in the gut microbiome and a healthy inflammatory response following ingestion.
Modulates inflammatory cytokines
Neuroinflammation modulating
Diminishes glial cell activation
Stimulates nerve growth factor synthase (NGFS)
Nootropic; neuroprotective
Stimulates nerve growth factor synthase (NGFS); inhibits plaque growth; promotes hippocampal neurogenesis
Cordyceps supports cellular energy production and may buffer the physiological effects of stress, improving both cognitive and physical aspects of anxiety, while modulating neurotransmitters and mitigating the mood and energy changes associated with long-term stress. Cordyceps also enhances memory by improving mitochondrial function and increasing blood flow to the brain, which supports energy production and oxygen delivery to brain cells. Its antioxidant and anti-inflammatory properties further protect neurons from damage, promoting cognitive resilience and improved memory performance.
Adaptogenic (stimulating)
Attenuates IgE production; reduces eotaxin, ICAM-1, IL-4, IL-5, IL-13 production
Protects mitochondria via ROS scavenging, increased antioxidase activity, & inhibition of mitochondrial swelling
Stimulates lactic acid dehydrogenase; increases free radical scavenging activity after exercise; increases VEGF activity
Increases NK cells, IFN-γ, and IL-2
Suppresses NF-kB activity; decreases iROS/PI3K/AKT/mTOR pathway activity
Regulates kidney function studies; inhibits TGF-β
Neurotransmitter modulating
Regulates dopamine & serotonin levels, improving neuronal signaling and stress resilience
Respiratory tonic (reduces airway reactivity and remodeling)
Inhibits inflammatory airway remodeling via down-regulation of TGF-β
Vasorelaxant via production of endothelial nitric oxide synthase (eNOS)
Reishi mushroom is known as the mushroom of immortality, and improves both quality of life and lifespan through multiple mechanisms. Reishi helps your body regulate acute and chronic stress, enhances natural immunity while modulating inflammation, supports sleep quality, and modulates sex hormone function.
Modulates cortisol signalling & the HPA axis
Inhibits lipid peroxidation
Inhibits histamine release; modulates Th1/Th2 polarization
Inhibits neuraminidase; promotes NK cell and cytotoxic T cell activity
Inhibits xanthine oxidase
Inhibits aldose reductase and α- glucosidase
Increases p53 tumor suppressor gene expression; upregulates caspase-3 expression
Inhibits angiotensin-converting enzyme (ACE)
Neuroinflammation modulating
Modifies microbiome composition, inhibits inflammasome activation, and enhances peripheral immune regulation, reducing neuroinflammation
Oyster mushroom is best known as a delicious food, and is rich in the amino acid ergothioneine, which easily crosses the blood brain barrier and accumulates in neurons. It supports a healthy response to oxidative damage, preventing damage to neurons over time, and promotes the maintenance of healthy memory.
Modulates IgE production; reduces eosinophilia
Diminished lipid peroxidation; inhibits HMG-CoA reductase; inhibits angiotensin-converting enzyme (ACE)
Increases NK cells; reduces frequency of respiratory infections
Inflammation modulating (topically)
β-glucan-induced modulation of inflammation
Neuroprotective; antioxidant
Reduced neuronal oxidative stress
Tremella is made up of almost 90% polysaccharides, compared to a more typical 30% in many mushrooms. These polysaccharides act as prebiotics for gut bacteria, promoting a healthy gut microbiome. In a randomized controlled trial, tremella demonstrated efficacy in supporting a healthy memory, executive function, and increased subjects’ gray matter brain volume.
Delays gastric emptying; increases insulin secretion
Increases gray matter brain volume
Digestion of polysaccharides by beneficial microbiota
Lucidum Medicinals is the only mushroom brand founded and formulated by physicians. Dr. Anna brings her decade of experience in mycology and natural medicine to each formulation so that every patient gets what they need, and none of what they don’t. See what other practitioners are saying about Lucidum formulas below.
Our mushrooms are tested extensively to guarantee not only safety but potency. Each is tested for key active ingredients, like beta-glucans and terpenoids, as well as for the absence of the alpha-glucans you would find in myceliated grains or “full spectrum” mushroom products.
We use potent 100% fruiting body only, so you get the most out of each mushroom. What we know as a mushroom is the fruiting body - what we see above ground, and can harvest in the wild. The below-ground mycelium part of the fungus has no traditional use, and, crucially, cannot be separated from what it’s growing on. Commercial mycelium products are grown on fermented grain - which makes up a substantial portion of the final product.
Our formulas are carefully crafted for each body system, informed by available scientific evidence and traditional use, using only the mushrooms that matter. Other brands sell either single mushrooms or “blends” that throw the kitchen sink at you. Single mushrooms lack synergism, while blends with 5+ ingredients lack focus and specificity.
The active molecules in mushrooms are a major component of the fungal cell wall, making them hard to digest and absorb. Our formulas use fruiting body extracted in water and alcohol that is easy to absorb and highly bioavailable so you get the most out of your mushroom medicine.
Mushrooms and natural medicine are not a trend for us - we founded Lucidum Medicinals on a backbone of 10+ years of experience in mycology and natural medicine. We use mushrooms to support a deep life of connection, love, and vitality for our families, our communities, and our patients. We hope you will too.
Dr. Anna Sitkoff, ND
Naturopathic Physician
Co-founder, Chief Science Officer
I first encountered medicinal mushrooms over 10 years ago during my father’s treatment for leukemia, which changed the course of my life.
In the 10 years since, I:
Started educating the public and professionals about medicinal mushrooms
Completed research on medicinal mushrooms and leukemia cells and published in the Journal of Immunology
Wrote the Medicinal Mushrooms chapter in The Textbook of Natural Medicine
Opened the doors of my naturopathic practice
Finally, I founded Lucidum Medicinals to provide effective mushroom formulas to my patients, my colleagues, and to you.
Using our Formulas Successfully
Targeted support for key systems
Immune system
Nervous system
Respiratory system
Take your formula for 90 days
Use the loading dose: 6 capsules daily
Benefits have been accumulating
Reassess your daily dose
Continue compounding benefits
Frequently asked questions
Each of our formulas is designed with the same total dose of 3g daily, in either powders (equivalent to 1.5 teaspoons) or capsules (6 capsules), and each formula label has specifics for the optimal number of doses per day, and timing. We recommend taking 3g total, daily, for at least 3 months in order to get the best results; after 3 months, you can consider reducing your dose to 1.5g total, daily, though benefits will continue to accrue at the therapeutic dose of 3g total daily. Benefits will usually diminish within a few weeks if you stop taking a formula.
Both the LUNGS and BRAIN & NERVES formulas are okay to take with food, but we recommend taking the IMMUNE formula away from food (liquids are okay) so that the active constituents can interact directly with the intestinal lining without interference. In general, optimal immune benefits from any medicinal mushroom are achieved on an empty stomach. Notably, we do not recommend blending our mushrooms with coffee, tea, or chocolate under any circumstances to prevent interference from tannins and other compounds found in these plants.
Every batch of mushrooms is tested to a minimum potency standard based on the beta glucan content of each mushroom, as well as mushroom-specific constituent concentrations. Mushrooms are also tested to confirm the absence of alpha-glucans, a marker for contamination with mycelium or growth substrate. You can learn more about these standards here.
In short, it means certain active constituents are concentrated 8-10x compared to a typical extract. Let’s use 8:1 as an example (like our Cordyceps powdered extract found in the LUNGS formula). Fruiting body is harvested, dried, and extracted in water and/or alcohol before being powdered. If you start with 1g of dried mushroom, and the powdered extract yields 1g, this is a 1:1 extract. If the same 1g of powdered extract was obtained from 8g of pre-extracted dried mushroom, we call it 8:1, representing an 8x concentration. With mushrooms, this process leads to lower levels of beta-glucans but much higher levels of other key constituents like terpenes, which is why we use concentrated extracts specifically for Lion’s mane, Reishi, and Cordyceps, depending on the formula.
Absolutely - each formula is designed to be complimentary, with the following note: both the BRAIN & NERVES and LUNGS formulas offer some immune benefit, though they are not as strong as the IMMUNE formula. If you decide to take both BRAIN & NERVES and LUNGS, you don’t need to take IMMUNE in addition. Combining the IMMUNE formula with either BRAIN & NERVES or LUNGS, or LUNGS with BRAIN & NERVES is quite impactful in our clinical experience.
On the optimal dose of 3g total, daily, of each formula, you will experience much of the benefit after 3 months. Additional benefits often continue to accrue over time.
Many brands sell either single mushrooms or “blends” that throw the kitchen sink at you. Single mushrooms lack synergism, while blends with 5+ ingredients lack focus and specificity. Our formulas are carefully crafted for each body system, informed by available scientific evidence and traditional use, using only the mushrooms that matter.
If you're a practitioner or have a retail location, we'd love to work with you. Potential wholesale partners can reach out to us at hello@lucidummedicinals.com, or fill out this form to request samples and sales materials. We look forward to hearing from you!
Have a questions we haven't answered? Ask us at hello@lucidummedicinals.com
10920 NE State Highway 104
Kingston, WA 98346
hello@lucidummedicinals.com
hello@lucidummedicinals.com
10920 NE State Hwy 104 Kingston, WA 98346
Copyright © 2026 Lucidum Medicinals, LLC. All Rights Reserved.
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